Glucose-responsive Insulin - Precision Diabetes Management

Glucose-Responsive Insulin is an innovative type of insulin that automatically adjusts its release based on glucose levels in the body, offering more precise blood sugar control for individuals with diabetes.

Glucose-responsive Insulin FAQ

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What is glucose responsive insulin (GRI)?

By subscribing, you agree to our Terms and Privacy Policy Glucose responsive insulin (GRI), known as smart insuli, is a promising treatment option for people with diabetes that, if successful, could result in blood glucose levels remaining within range during the day.

What is molecular glucose-responsive insulin?

Molecular glucose-responsive insulin represents another important strategy that focuses on the modification of insulin to generate engineered insulin analogs with glucose-dependent properties [ 73, 95., 96., 97.] ( Figure 1 C).

What is glucose-responsive insulin release utilizing Con a?

Another type of glucose-responsive insulin release utilizing Con A was constructed by conjugating insulin to one or more glucose molecules, which can then tether insulin to the Con A-constituted hydrogels.

What is the mechanism for glucose-responsive insulin release?

(a) The mechanism for glucose-responsive insulin release. A skin at the surface of the gel formed at low glucose level, inhibiting the insulin release; at high glucose levels, the skin was hydrated and allowed the insulin permeation. (b) The gel was loaded into a silicone catheter with the “skin” layer as the gate.

What is a self-regulated glucose-responsive insulin delivery system?

A recent development is the self-regulated glucose-responsive insulin delivery system by which a single administration lasts for a long time and autonomously delivers the drug in response to the change in the blood sugar level to maintain a normal blood sugar level 6, 7, 8, 9.