SGLT Inhibitors: Oral Medications for Diabetes Management

SGLT inhibitors are a class of oral medications used to lower blood sugar levels in patients with type 2 diabetes. They work by blocking glucose reabsorption in the kidneys.
Where to get
Available with a prescription at pharmacies and clinics.
Prepared by Lee Cheng, reviewed by Jane Cox

SGLT Inhibitors FAQ

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What are SGLT2 inhibitors?

SGLT2 inhibitors are tablets that can help to lower your blood glucose (sugar) levels. If you have type 2 diabetes, your doctor may prescribe them as part of your treatment plan. There are several different tablets in the SGLT2 group. How do SGLT2 inhibitors work? SGLT2 inhibitors can help to lower your blood sugar levels by:

What does SGLT2 stand for?

Stay up to date with the latest news, research and breakthroughs. Sodium-glucose co-transporter-2 (SGLT2) inhibitors are used for treating type 2 diabetes by helping the kidneys to lower blood glucose levels.

Do SGLT2 inhibitors cause low blood sugar?

If you take other diabetes medications to manage your blood sugar levels, adding an SGLT2 inhibitor increases your risk of developing low blood sugar. In addition, if you’re taking certain types of diuretics, SGLT2 inhibitors can increase their effect, causing you to urinate more often.

Can SGLT2 inhibitors help with kidney disease?

Some SGLT2 inhibitors are FDA approved to help slow the progression of kidney disease. One type of SGLT2 inhibitor is now FDA-approved to help improve blood sugar control in children 10 years and older with type 2 diabetes. Studies are underway to see if SGLT2 inhibitors can be helpful for some kidney diseases in children who do not have diabetes.

Are SGLT2 inhibitors good for 2 diabetes?

2 diabetes on SGLT2 inhibitors. This leaflet provides information regarding benefits, possible side effects including DKA and circumstances in which patients need to seek medical advice. What are SGLT2 inhibitors? • SGLT2 inhibitors are a class of drugs used in the treatment of diabetes.

Do SGLT2 inhibitors lower blood pressure?

This is because SGLT2 inhibitors can also lower blood pressure by removing excess water from the body. Your doctor, pharmacist or nurse may need to adjust doses of these medicines. • Your doctor may want to reduce the dose of other diabetes medicines, such as insulin or gliclazide. This is to avoid your blood sugar levels from getting too low.

How many SGLT-2 inhibitors are available in the UK?

There are four SGLT-2 inhibitors available in the UK. The recommended doses are: Recommended starting dose is 100 mg once daily, increased to 300 mg once daily if needed, dose to be taken preferably before breakfast. Recommended dose is 10 mg once daily.

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